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Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine. When chronic kidney disease reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes can build up in your body.
In the early stages of chronic kidney disease, you may have few signs or symptoms. Chronic kidney disease may not become apparent until your kidney function is significantly impaired.
Treatment for chronic kidney disease focuses on slowing the progression of the kidney damage, usually by controlling the underlying cause. Chronic kidney disease can progress to end-stage kidney failure, which is fatal without artificial filtering (dialysis) or a kidney transplant.
Anemia (likewise spelled anaemia) is a lessening in the aggregate sum of red platelets (RBCs) or hemoglobin in the blood, or a brought capacity of the blood down to convey oxygen. When paleness goes ahead gradually, the indications are regularly obscure and may incorporate inclination tired, shortcoming, brevity of breath, and a poor capacity to exercise. When the pallor goes ahead rapidly, side effects may incorporate disarray, feeling like one is going to drop, loss of awareness, and expanded thirst. Anemia must be critical before an individual turns out to be recognizably pale. Additional manifestations may happen contingent upon the fundamental reason.
Macrocytic anemia is a type of anemia that causes unusually large red blood cells. Like other types of anemia, macrocytic anemia means that the red blood cells also have low hemoglobin.
Hemoglobin is an iron-containing protein that transports oxygen around the body. Deficiencies in vitamin B-12 or folate often cause macrocytic anemia, so it is sometimes called vitamin deficiency anemia.
Macrocytic anemia occurs if the red blood cells are unusually large. A unit called femtoliters (fL) is used to measure the size of blood cells. Usually, red blood cells are between 80?100 fL.
Red blood cells larger than 100 fL are considered macrocytic. When the cells grow too large, there are fewer of them than there needs to be and they carry less hemoglobin. This means the blood is not as oxygen-rich as it should be. Low blood oxygen can cause a range of symptoms and health problems.
Macrocytic anemia is not a single disease, but a symptom of several medical conditions and nutritional problems.
One of the most common types of macrocytic anemia is megaloblastic macrocytic anemia. This happens when red blood cells produce DNA too slowly to divide.
Macrocytic anemia can be broken into two main types: megaloblastic and nonmegaloblastic macrocytic anemias.
Most macrocytic anemias are also megaloblastic. Megaloblastic anemia is a result of errors in your red blood cell DNA production. This causes your body to make red blood cells incorrectly.
Possible causes include:
Nonmegaloblastic forms of macrocytic anemia may be caused by a variety of factors. These can include:
Cystic fibrosis is an inherited disease characterized by the buildup of thick, sticky mucus that can damage many of the body's organs. The disorder's most common signs and symptoms include progressive damage to the respiratory system and chronic digestive system problems. The features of the disorder and their severity varies among affected individuals.
Mucus is a slippery substance that lubricates and protects the linings of the airways, digestive system, reproductive system, and other organs and tissues. In people with cystic fibrosis, the body produces mucus that is abnormally thick and sticky. This abnormal mucus can clog the airways, leading to severe problems with breathing and bacterial infections in the lungs. These infections cause chronic coughing, wheezing, and inflammation. Over time, mucus buildup and infections result in permanent lung damage, including the formation of scar tissue (fibrosis) and cysts in the lungs.
Most people with cystic fibrosis also have digestive problems. Some affected babies have meconium ileus, a blockage of the intestine that occurs shortly after birth. Other digestive problems result from a buildup of thick, sticky mucus in the pancreas. The pancreas is an organ that produces insulin (a hormone that helps control blood sugar levels). It also makes enzymes that help digest food. In people with cystic fibrosis, mucus often damages the pancreas, impairing its ability to produce insulin and digestive enzymes. Problems with digestion can lead to diarrhea, malnutrition, poor growth, and weight loss. In adolescence or adulthood, a shortage of insulin can cause a form of diabetes known as cystic fibrosis-related diabetes mellitus (CFRDM).
Cystic fibrosis used to be considered a fatal disease of childhood. With improved treatments and better ways to manage the disease, many people with cystic fibrosis now live well into adulthood. Adults with cystic fibrosis experience health problems affecting the respiratory, digestive, and reproductive systems. Most men with cystic fibrosis have congenital bilateral absence of the vas deferens (CBAVD), a condition in which the tubes that carry sperm (the vas deferens) are blocked by mucus and do not develop properly. Men with CBAVD are unable to father children (infertile) unless they undergo fertility treatment. Women with cystic fibrosis may experience complications in pregnancy.
Heart rhythm problems (heart arrhythmias) occur when the electrical impulses that coordinate your heartbeats don't work properly, causing your heart to beat too fast, too slow or irregularly.
Heart arrhythmias (uh-RITH-me-uhs) may feel like a fluttering or racing heart and may be harmless. However, some heart arrhythmias may cause bothersome ? sometimes even life-threatening ? signs and symptoms.
Heart arrhythmia treatment can often control or eliminate fast, slow or irregular heartbeats. In addition, because troublesome heart arrhythmias are often made worse ? or are even caused ? by a weak or damaged heart, you may be able to reduce your arrhythmia risk by adopting a heart-healthy lifestyle.
Doctors classify arrhythmias not only by where they originate (atria or ventricles) but also by the speed of heart rate they cause:
Blood sugar control is at the center of any diabetes treatment plan. High blood sugar, or hyperglycemia, is a major concern, and can affect people with both type 1 and type 2 diabetes . There are two main kinds:
Frequent or ongoing high blood sugar can cause damage to your nerves, blood vessels, and organs. It can also lead to other serious conditions. People with type 1 diabetes are prone to a build-up of acids in the blood called ketoacidosis.
If you have type 2 diabetes or if you?re at risk for it, extremely high blood sugar can lead to a potentially deadly condition in which your body can?t process sugar. It's called hyperglycemic hyperosmolar nonketotic syndrome (HHNS). You?ll pee more often at first, and then less often later on, but your urine may become dark and you could get severely dehydrated.
High blood sugar (hyperglycemia) affects people who have diabetes. Several factors can contribute to hyperglycemia in people with diabetes, including food and physical activity choices, illness, nondiabetes medications, or skipping or not taking enough glucose-lowering medication.
It's important to treat hyperglycemia, because if left untreated, hyperglycemia can become severe and lead to serious complications requiring emergency care, such as a diabetic coma. In the long term, persistent hyperglycemia, even if not severe, can lead to complications affecting your eyes, kidneys, nerves and heart.
Angina is a type of chest pain caused by reduced blood flow to the heart. Angina (an-JIE-nuh or AN-juh-nuh) is a symptom of coronary artery disease.
Angina, also called angina pectoris, is often described as squeezing, pressure, heaviness, tightness or pain in your chest. Some people with angina symptoms say angina feels like a vise squeezing their chest or a heavy weight lying on their chest. Angina may be a new pain that needs to be checked by a doctor, or recurring pain that goes away with treatment.
Although angina is relatively common, it can still be hard to distinguish from other types of chest pain, such as the discomfort of indigestion. If you have unexplained chest pain, seek medical attention right away.
There are several types of angina.
Stable angina occurs when the heart is working harder than usual, for instance, during exercise. It has a regular pattern and can be predicted to happen over months or even years. Rest or medication relieves symptoms.
Unstable angina does not follow a regular pattern. It can occur when at rest and is considered less common and more serious because rest and medication do not relieve it. This version can signal a future heart attack within a short time ? hours or weeks.
Variant or Prinzmetal?s angina and microvascular angina are rare and can occur at rest without any underlying coronary artery disease. This angina is usually due to abnormal narrowing or relaxation of the blood vessels, reducing blood flow to the heart. It can be relieved by medicine.
