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Total Triiodothyronine (T3)

Total Triiodothyronine (T3):Total Triiodothyronine (T3)

Overview

Triiodothyronine (T3) is one of two major hormones produced by the thyroid gland, a small butterfly-shaped organ that lies flat across the windpipe at the base of the throat. The other major thyroid hormone is called thyroxine (T4) and together they help control the rate at which the body uses energy. Almost all of the T3 (and T4) found in the blood is bound to protein. The rest is free (unbound) and is the biologically active form of the hormone. Tests can measure the amount of free T3 or the total T3 (bound plus unbound) in the blood.

Pituitary-Thyroid Feedback System

T3 and T4 production is regulated by a feedback system. When blood levels of thyroid hormones decline, the hypothalamus releases thyrotropin releasing hormone, which stimulates the pituitary gland to produce and release thyroid-stimulating hormone (TSH). TSH then stimulates the thyroid gland to produce and/or release more thyroid hormones. Most of the thyroid hormone produced is T4. This hormone is relatively inactive, but it is converted into the much more active T3 in the liver and other tissues.

If the thyroid gland produces excessive amounts of T4 and T3, then the person affected may have symptoms associated with hyperthyroidism, such as nervousness, tremors of the hands, weight loss, insomnia, and puffiness around dry, irritated eyes. In some cases, the person's eyes cannot move normally and they may appear to be staring. In other cases, the eyes may appear to bulge.

If the thyroid gland produces insufficient amounts of thyroid hormones, then the person may have signs and symptoms associated with hypothyroidism and a slowed metabolism, such as weight gain, dry skin, fatigue, and constipation. The blood levels of thyroid hormones may be low or high due to thyroid dysfunction or rarely due to insufficient or excessive TSH production related to a pituitary disorder.

The most common causes of thyroid dysfunction are related to autoimmune disorders. Graves disease causes hyperthyroidism, but it can also be caused by thyroiditis, thyroid cancer, and excessive production of TSH. The effect of these conditions on thyroid hormone production can be detected and monitored by measuring the free T3 or sometimes total T3.

Preparation(Before)

It?s important to tell your doctor about all of the medications you?re currently taking, as some may affect your T3 test results. If your doctor knows about your medications in advance, they can advise you to temporarily stop using them or consider their effect when interpreting your results.

Some medications that can affect your T3 levels include:

  • thyroid-related drugs
  • steroids
  • birth control pills or other medications containing hormones, such as androgens and estrogens

Preparation(On-time)

The T3 test simply involves having your blood drawn. The blood will then be tested in a laboratory.

Typically, normal results range from 100 to 200 nanograms per deciliter (ng/dL).

A normal T3 test result doesn?t necessarily mean that your thyroid is functioning perfectly. Measuring your T4 and TSH can help your doctor figure out if you have a thyroid problem despite a normal T3 result.

Normal range

Pediatric

0-5 days: 73-288 ng/dL

6 days-2 months: 80-275 ng/dL

3-11 months: 86-265 ng/dL

1-5 years: 92-248 ng/dL

6-10 years: 93-231 ng/dL

11-19 years: 91-218 ng/dL

Adult (> or =20 years): 80-200 ng/dL

Result explanation

If your results show high total T3 levels or high free T3 levels, it may mean you have hyperthyroidism. Low T3 levels may mean you have hypothyroidism, a condition in which your body doesn't make enough thyroid hormone.

T3 test results are often compared with T4 and TSH test results to help diagnose thyroid disease.

Common uses

Hyperthyroidism; Hypothyroidism

Global facts

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Customer support

"We can help and guide you to find answer to your queries. Some sample questions we answered for our customers are:

You can also call us at 9503472446 or email us at customercare@ihealthmantra.com or chat with our customer support."

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