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Iron-deficiency anemia

Iron-deficiency anemia

Overview

Megaloblastic anemia, a group of diseases characterized by large red blood cells (RBCs), is a form of macrocytic anemia. The condition results from impaired DNA synthesis and consequent defective erythrocyte maturation. Megaloblastic anemia is common in adults older than 60 years (a demographic group that continues to grow in the United States) and is associated with significant morbidity. 1 Causes of megaloblastic anemia include vitamin B12 (cobalamin) or folate (vitamin B9) deficiency and specific drugs. 2 , 3 Vitamin B12 deficiency and associated megaloblastic anemia may be caused by pernicious anemia, in which a lack of intrinsic factor (IF) prevents sufficient absorption of vitamin B12. 3 The initial evaluation for megaloblastic anemia includes a CBC and review of a peripheral blood smear. 2 Additional testing for vitamin B12 and/or folate deficiency and antibody testing for pernicious anemia may be performed based on the results of these initial tests. 3

Preparation(Before)

Overnight fasting is mandatory. Wrap tube in aluminium foil to protect from light.

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